De Ligt sustained a muscular injury in the 33rd minute of United's 4-3 defeat at Brentford in the Premier League on Sunday.

Manager Ruben Amorim, who has overseen an impressive European run in his first season at the helm, will have to weigh up his defensive options in De Ligt’s likely absence with Diogo Dalot, Lisandro Martinez and Johhny Evans also unavailable.

Ruben Amorim provides Matthijs de Ligt update after fresh injury blow - De Ligt had only just returned to action after injury but could face another setback