The San Fransico 49ers travel to the desert to take on the Las Vegas Raiders in Game 2 of the 2025 NFL preseason for both teams. The 49ers are fresh off a 30-9 shellacking by the Denver Broncos in the first preseason game on Aug.

Expert recap and game analysis of the San Francisco 49ers vs. Las Vegas Raiders NFL game from August 16, 2025 on ESPN.

The second preseason game versus the Las Vegas Raiders was more entertaining for the San Francisco 49ers than the first. Part of that is because the starters got a bit of action, but it's also because the 49ers had some players stand out.

The injury-riddled 49ers do have some players worth watching in Saturday’s preseason visit to the Raiders after possible cameos by select starters.

The San Francisco 49ers and the Las Vegas Raiders face off in Week 2 of the NFL preseason today. Here's where to watch and start time.

Second-year starting right guard Dominick Puni, one of the bright spots of an otherwise grim 2024 season for the 49ers, is expected to miss multiple weeks with a suspected PCL injury. It appears the injury occurred after he was rolled up on during Jake Moody’s first quarter field goal attempt.

The Las Vegas Raiders suffered a dramatic loss last Saturday to their old rivals from the Bay, the San Francisco 49ers. While the results will be washed away with the beginning of the regular season, the lessons learned in the preseason will predict the strength of their roster.

For the 49ers their health has become a greater concern than their preseason performance. They just need to make sure they have enough healthy bodies to keep their key starters out of harm's way. More than 20 players missed their preseason opener vs. the Denver Broncos with injuries, and that number could rise Saturday when they face the Raiders.